Passive immunization studies show similar efficacy in reducing brain A/amyloid and preserving memory in transgenic mouse models of AD [13,14], but the passive immunization approach is also limited by excessive neuroinflammation and vasogenic edema in a subset of treated individuals with AD

Passive immunization studies show similar efficacy in reducing brain A/amyloid and preserving memory in transgenic mouse models of AD [13,14], but the passive immunization approach is also limited by excessive neuroinflammation and vasogenic edema in a subset of treated individuals with AD. Passive immunization may reduce brain Fosdagrocorat A by at least two distinct mechanisms…