In mice, anti-CD22 treatment, has been proven to deplete B cells in spleen, bone tissue marrow, lymph nodes and peripheral blood and since CD22 is portrayed on CD138+ plasma cells also, it decreases antibody production[18]
In mice, anti-CD22 treatment, has been proven to deplete B cells in spleen, bone tissue marrow, lymph nodes and peripheral blood and since CD22 is portrayed on CD138+ plasma cells also, it decreases antibody production[18]. such as for example secretion of immuno-suppressive cytokines interleukin-10 (IL-10) or IL-35, cytotoxicity, appearance of inhibitory receptors or by secretion…