The BR3+/CD14+ ratios of pSS patients were calculated based on the FACS results

The BR3+/CD14+ ratios of pSS patients were calculated based on the FACS results. < 0.05 was considered significant. (PPTX 58 kb) 13075_2020_2249_MOESM3_ESM.pptx (58K) GUID:?7950068E-8DFE-43DB-A8CB-8FBAF63E96F3 Additional file 4: Figure S4. Correlation between the proportion of CD14+ monocytes and serum IgG and IgM levels in individuals. The proportion of CD14+ monocytes among peripheral white blood cells of pSS individuals was calculated based on the results of FACS. Serum levels of IgG (A) and IgM (B) were plotted against the proportion of CD14+ monocytes for each patient. Pearsons correlation analysis was used to examine the relationship between the guidelines. A p value < 0.05 was considered significant. (PPTX 56 kb) 13075_2020_2249_MOESM4_ESM.pptx (57K) GUID:?3D35A0DE-24C4-49C3-BCD6-DE4D3AAD1F3B Additional file 5: Number S5. Correlation between the TACI+/CD14+ ratios and medical features of individuals with pSS. TACI+/CD14+ ratios in pSS individuals were calculated based on the FACS results. Serum levels of IgG (A) and IgM (B) were plotted against the TACI+/CD14+ ratios for each patient. The ratios were plotted against their ESSDAI score Bucetin for each individual (C). Pearsons correlation analysis was used to evaluate the linear relationship between two continuous variables. (PPTX 67 kb) 13075_2020_2249_MOESM5_ESM.pptx (67K) GUID:?D51D2BA9-FA3B-492A-B80F-305EA9F1FD0C Additional file 6: Figure S6. Correlation between the BR3+/CD14+ ratios and the age of individuals with pSS. The BR3+/CD14+ ratios of pSS individuals were calculated based on the FACS results. Bucetin The BR3+/CD14+ percentage was plotted against the age for each individual. Pearsons correlation analysis was examined for statistical significance between the organizations. A p value < 0.05 was considered Bucetin significant. (PPTX 49 kb) 13075_2020_2249_MOESM6_ESM.pptx (49K) GUID:?B28BE2E6-D0B4-4C57-B6FE-C4390DDBF8F9 Data Availability StatementAll data generated and analyzed with this study are disclosed in this article. Abstract Background We reported the production of BAFF (B cell-activating element) and IL-6, both of which are involved in survival and differentiation of B cells, is Bucetin definitely dysregulated in monocytes of individuals with main Sj?grens syndrome (pSS). In this study, we investigate the relationship between possible aberrations of pSS monocytes and medical features of pSS individuals and the contribution of monocytes to B cell activation, a mechanism involved in the pathogenesis of pSS. Methods Manifestation of BAFF-receptor (BR3) on peripheral monocytes from individuals with pSS (test for single assessment, unless otherwise noted. Pearsons correlation analysis was employed to evaluate the linear relationship between two continuous variables. A value of less than 0.05 was used to indicate a statistically significant difference. Results Laboratory parameter abnormalities of pSS individuals We investigated the laboratory guidelines of the pSS individuals enrolled in this study (Table?1). The average IgG serum level was 1653??587?mg/dl, and 32.8% of individuals experienced serum IgG levels above the research range of normal Japanese individuals (870C1700?mg/dl) [35] (Table?1). Although pSS individuals aged 65?years or older are reportedly less likely to possess HG [36], we found no significant difference was observed in the prevalence of HG between younger individuals (35.3%; value Lum positive and significant correlation between the BR3+/CD14+ percentage and serum levels of IgG (test for single assessment. *= 37), pSS individuals (= 67), SLE individuals (untreated, = 20) and RA individuals (untreated, = 14) were incubated with phycoerythrin-labeled anti-BR3 and Pacific Blue-labeled anti-CD14 mAbs. The BR3+/CD14+ percentage was analyzed by FACS. Horizontal lines show mean. ** value < 0.05 was considered significant. (PPTX 58 kb)(58K, pptx) Additional file 4: Number S4. Correlation between the proportion of CD14+ monocytes and serum IgG and IgM.

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