The molecular pathogenesis of primary mediastinal large B-cell lymphoma

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The molecular pathogenesis of primary mediastinal large B-cell lymphoma. of PMBL cases. 0.05. Acknowledgments We thank Julia Kiedaisch, Iwona Nerbas, and Birgit Schif for excellent technical assistance. Footnotes Authorship and Disclosures: MTH, KL, KD, PM and OR designed experiments; MTH, KD, and KL performed the laboratory work for this study; OR, MTH, KD, and PM wrote the manuscript, and all authors approved the final version. The authors reported no potential conflict of interest REFERENCES 1. Dunleavy K, Pittaluga S, Maeda LS, Advani R, Chen CC, Hessler J, Steinberg SM, WIN 55,212-2 mesylate Grant C, Wright G, Varma G, Staudt LM, Jaffe ES, Wilson WH. Dose-adjusted EPOCH-rituximab therapy in primary mediastinal B-cell lymphoma. N.Engl.J.Med. 2013;368:1408C1416. [PMC free article] [PubMed] [Google Scholar] 2. Steidl Gascoyne. The molecular pathogenesis of primary mediastinal large B-cell lymphoma. Blood. 2011;118:2659C2669. [PubMed] [Google Scholar] 3. De Leval L, Ferry JA, Falini B, Shipp M, Harris NL. Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells? Am.J.Surg.Pathol. 2001;25:1277C1282. [PubMed] [Google Scholar] 4. Malpeli G, Barbi S, Moore PS, Scardoni M, Chilosi M, Scarpa A, Menestrina F. Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. Haematologica. 2004;89:1091C1099. [PubMed] [Google Scholar] 5. Palanisamy N, Abou-Elella AA, Chaganti SR, Houldsworth J, Offit K, Louie DC, Terayu-Feldstein J, Cigudosa JC, Rao PH, Sanger WG, Weisenburger DD, Chaganti RS. Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma. Genes Chromosomes.Cancer. 2002;33:114C122. [PubMed] [Google Scholar] 6. Guiter C, Dusanter-Fourt I, Copie-Bergman C, Boulland ML, Le GS, Gaulard P, Leroy K, Castellano F. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood. 2004;104:543C549. [PubMed] [Google Scholar] 7. Ritz O, Rommel K, Dorsch K, Kelsch E, Melzner J, Buck M, Leroy K, Papadopoulou V, Wagner S, Marienfeld R, Brderlein S, Lennerz JK, M?ller P. STAT6-mediated BCL6 repression in Mouse monoclonal to KARS primary mediastinal B-cell lymphoma (PMBL) Oncotarget. 2013;4:1093C1102. [PMC free article] [PubMed] [Google Scholar] 8. Ritz O, Guiter C, Castellano F, Dorsch K, Melzner J, Jais JP, Dubois G, Gaulard P, M?ller P, Leroy K. Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma. Blood. 2009;114:1236C1242. [PMC free article] [PubMed] [Google Scholar] 9. Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, WIN 55,212-2 mesylate Dowdy SF, Melnick A. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood. 2009;113:3397C3405. [PMC free article] [PubMed] [Google Scholar] 10. Rui L, Emre NC, Kruhlak MJ, Chung HJ, Steidl C, Slack G, Wright GW, Lenz G, Ngo VN, Shaffer AL, Xu W, Zhao H, Yang Y, Lamy L, Davis RE, Xiao W, et al. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cel. 2010;18:590C605. [PMC free article] [PubMed] [Google Scholar] 11. Furqan M, Mukhi N, Lee B, Liu D. Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application. Biomark.Res. 2013;1:5. [PMC free article] [PubMed] [Google Scholar].Cooperative epigenetic modulation by cancer amplicon genes. R-CHOP components in two of three PMBL cell lines. In one cell line, MedB-1, which is marked by less expression of BCL6 and mutated STAT6, the knock-down of BCL6 / STAT6 did not enhance the efficiency of Doxorubicin, Rituximab, and Vincristin. Thus, the targeting of BCL6 and STAT6 in addition or prior to the treatment with components of the current immuno-chemotherapy may sensitize the PMBL tumor cells for drug effects, at least in parts of PMBL cases. 0.05. Acknowledgments We thank Julia Kiedaisch, Iwona Nerbas, and Birgit Schif for excellent technical assistance. Footnotes Authorship and Disclosures: MTH, KL, KD, PM and OR designed experiments; MTH, KD, and KL performed WIN 55,212-2 mesylate the laboratory work for this study; OR, MTH, KD, and PM wrote the manuscript, and all authors approved the final version. The authors reported no potential conflict of interest REFERENCES 1. Dunleavy K, Pittaluga S, Maeda LS, Advani R, Chen CC, Hessler J, Steinberg SM, Grant C, Wright G, Varma G, Staudt LM, Jaffe ES, Wilson WH. Dose-adjusted EPOCH-rituximab therapy in primary mediastinal B-cell lymphoma. N.Engl.J.Med. 2013;368:1408C1416. [PMC free article] [PubMed] [Google Scholar] 2. Steidl Gascoyne. The molecular pathogenesis of primary mediastinal large B-cell lymphoma. Blood. 2011;118:2659C2669. [PubMed] [Google Scholar] 3. De Leval L, Ferry JA, Falini B, Shipp M, Harris NL. Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells? Am.J.Surg.Pathol. 2001;25:1277C1282. [PubMed] [Google Scholar] 4. Malpeli G, Barbi S, Moore PS, Scardoni M, Chilosi M, Scarpa A, Menestrina F. Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. Haematologica. 2004;89:1091C1099. [PubMed] [Google Scholar] 5. Palanisamy N, Abou-Elella AA, Chaganti SR, Houldsworth J, Offit K, Louie DC, Terayu-Feldstein J, Cigudosa JC, Rao PH, Sanger WG, Weisenburger DD, Chaganti RS. Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphoma. Genes Chromosomes.Cancer. 2002;33:114C122. [PubMed] [Google Scholar] 6. Guiter C, Dusanter-Fourt I, Copie-Bergman C, Boulland ML, Le GS, Gaulard P, Leroy K, Castellano F. Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood. 2004;104:543C549. [PubMed] [Google Scholar] 7. Ritz O, Rommel K, Dorsch K, Kelsch E, Melzner J, Buck M, Leroy K, Papadopoulou V, Wagner S, Marienfeld R, Brderlein S, Lennerz JK, M?ller P. STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL) Oncotarget. 2013;4:1093C1102. [PMC free article] [PubMed] [Google Scholar] 8. Ritz O, Guiter C, Castellano F, Dorsch K, Melzner J, Jais JP, Dubois G, Gaulard P, M?ller P, Leroy K. Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma. Blood. 2009;114:1236C1242. [PMC free article] [PubMed] [Google Scholar] 9. Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A, Dowdy SF, Melnick A. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood. 2009;113:3397C3405. [PMC free article] [PubMed] [Google Scholar] 10. Rui L, Emre NC, Kruhlak MJ, Chung HJ, Steidl C, Slack G, Wright GW, Lenz G, Ngo VN, Shaffer AL, Xu W, Zhao H, Yang Y, Lamy L, Davis RE, Xiao W, et al. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cel. 2010;18:590C605. [PMC free article] [PubMed] [Google Scholar] 11. Furqan M, Mukhi N, Lee B, Liu D. Dysregulation of JAK-STAT pathway in hematological malignancies and JAK inhibitors for clinical application. Biomark.Res. 2013;1:5. [PMC free article] [PubMed] [Google Scholar].

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