To develop neutralizing MAbs, mice were infected with the 16007 (genotype 2) prototype strain of DENV-1 and in some cases, boosted with recombinant DIII from the homologous DENV-1 strain

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To develop neutralizing MAbs, mice were infected with the 16007 (genotype 2) prototype strain of DENV-1 and in some cases, boosted with recombinant DIII from the homologous DENV-1 strain. explain disparities in neutralizing potential of MAbs among different genotypes. Overall, our experiments define a complex structural epitope on DIII of DENV-1 that can be recognized…

Mitochondria were treated with 50 nM tBID or 13 nM tBID alone or in combination with GST-BHRF-1 (0

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Mitochondria were treated with 50 nM tBID or 13 nM tBID alone or in combination with GST-BHRF-1 (0.2 was measured by ELISA. of these BH3 domains to antagonize the anti-apoptotic protection afforded by BCL-2 and orthologs. Many and anti-Fas antibody,13,14 irradiation, chemo-therapeutic drugs,15,16 deregulated c-to humans. Viruses seem to have adapted the mechanism of inhibiting…

C: Intense Capture-1 staining in Gleason quality 3 tumor admixed with normal glands bad for Capture-1 manifestation (arrow)

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C: Intense Capture-1 staining in Gleason quality 3 tumor admixed with normal glands bad for Capture-1 manifestation (arrow). 1A, Desk 1). Conversely, regular prostatic glands admixed with tumor foci showed adverse, negligible or fragile staining for Capture-1 (Shape 1C, Desk 1). Atrophic harmless glands frequently discovered intermixed with tumor foci had been weakly stained for…