The regimen, first described by Anthony Fauci and Sheldon Wolfe for the treatment of WG, used daily oral cyclophosphamide (2 mg/kg/day time) for years, both to induce and maintain remission
The regimen, first described by Anthony Fauci and Sheldon Wolfe for the treatment of WG, used daily oral cyclophosphamide (2 mg/kg/day time) for years, both to induce and maintain remission.[74] Although effective, this regimen is associated with considerable toxicity, including infertility, malignancy, and hemorrhagic cystitis.[75] For this reason, substantial effort has been expended to find…