(b) Transfectant clones lost normal cell morphology and presented aberrant microtubule overgrowth
(b) Transfectant clones lost normal cell morphology and presented aberrant microtubule overgrowth. the family of heterogeneous nuclear ribonucleoproteins (hnRNP) H/F as candidate splicing Daptomycin factors potentially responsible for impairedTPsplicing. Indeed, whereas parental cells lacked nuclear localization of hnRNPs H1/H2 and F, drug-resistant cells harbored marked levels of these splicing factors. Nuclear RNA immunoprecipitation experiments established…