SIRT1 is necessary for SOX2 appearance in liver organ cancer tumor stem cells by inhibition and deacetylation of DNMT3B [100], as well as for EMT induction in breasts cancer tumor by deacetylation of H4K16 and H3K9 over the promoter of WNT inhibitors secreted frizzled protein SFRP1 and SFRP2 and of E-cadherin [101]

SIRT1 is necessary for SOX2 appearance in liver organ cancer tumor stem cells by inhibition and deacetylation of DNMT3B [100], as well as for EMT induction in breasts cancer tumor by deacetylation of H4K16 and H3K9 over the promoter of WNT inhibitors secreted frizzled protein SFRP1 and SFRP2 and of E-cadherin [101]. constant rewiring of…