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Br. AZD3839 free base of these enzymes suppresses nucleotide biosynthesis, resulting in an imbalance of purine and pyrimidine precursors, rendering cells incapable of undergoing accurate DNA replication, ultimately resulting in cell death. Clinically relevant TS and DHFR inhibitors, typified by pemetrexed (PMX), and methotrexate (MTX) and pralatrexate (Figure 1), respectively, continue to play important roles…