This also described the observations that NCI-H460/TPT10 cells shown no resistance to non-ABCG2 substrates such as for example paclitaxel, colchicine, vincristine, and cisplatin
This also described the observations that NCI-H460/TPT10 cells shown no resistance to non-ABCG2 substrates such as for example paclitaxel, colchicine, vincristine, and cisplatin. was within NCI-H460/TPT10 cells, indicating that ABCG2 was apt to be involved with topotecan-resistance. This is confirmed with the abolishment of medication level of resistance in NCI-H460/TPT10 cells after knockout. Furthermore, the…