Two week subcutaneous minipump treatment with NaDMDC at 50 mg/kg/day time resulted in persistent motor abnormalities typically seen in mice with dysfunction of the nigrostriatal pathway (38)
Two week subcutaneous minipump treatment with NaDMDC at 50 mg/kg/day time resulted in persistent motor abnormalities typically seen in mice with dysfunction of the nigrostriatal pathway (38). and a slight reduction in striatal TH staining but no nigral cell loss. These results demonstrate that ziram causes selective dopaminergic cell damage by inhibiting an important degradative…